GO:0004252 serine-type endopeptidase activity GO:0050840 extracellular matrix binding GO:0008066 glutamate receptor activity GO:0016866 intramolecular transferase activity GO:0044325 ion channel binding GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses GO:0016860 intramolecular oxidoreductase activity GO:1902936 EXPLANATION GO:0004659 prenyltransferase activity GO:0000166 nucleotide binding GO:0004714 transmembrane receptor protein tyrosine kinase activity GO:0004713 protein tyrosine kinase activity GO:0004896 cytokine receptor activity GO:0030594 neurotransmitter receptor activity GO:0017171 serine hydrolase activity GO:0000988 protein binding transcription factor activity GO:0001067 regulatory region nucleic acid binding GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0046332 SMAD binding GO:0050839 cell adhesion molecule binding GO:0030295 protein kinase activator activity GO:0044212 transcription regulatory region DNA binding GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0016817 hydrolase activity, acting on acid anhydrides GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines GO:0016769 transferase activity, transferring nitrogenous groups GO:0015078 hydrogen ion transmembrane transporter activity GO:0022804 active transmembrane transporter activity GO:0004623 phospholipase A2 activity GO:0004620 phospholipase activity GO:0016773 phosphotransferase activity, alcohol group as acceptor GO:0031072 heat shock protein binding GO:0008483 transaminase activity GO:0030170 pyridoxal phosphate binding GO:1901265 nucleoside phosphate binding GO:0008565 protein transporter activity GO:0015491 cation:cation antiporter activity GO:0003779 actin binding GO:0015399 primary active transmembrane transporter activity GO:0043021 ribonucleoprotein complex binding GO:0017076 purine nucleotide binding GO:0043022 ribosome binding GO:0042826 histone deacetylase binding GO:0003774 motor activity GO:0022836 gated channel activity GO:0016787 hydrolase activity GO:0016782 transferase activity, transferring sulfur-containing groups GO:0016780 phosphotransferase activity, for other substituted phosphate groups GO:0019887 protein kinase regulator activity GO:0019888 protein phosphatase regulator activity GO:0022834 ligand-gated channel activity GO:0016788 hydrolase activity, acting on ester bonds GO:0004842 ubiquitin-protein ligase activity GO:0004843 ubiquitin-specific protease activity GO:0015081 sodium ion transmembrane transporter activity GO:0030674 protein binding, bridging GO:0051539 4 iron, 4 sulfur cluster binding GO:0004536 deoxyribonuclease activity GO:0016772 transferase activity, transferring phosphorus-containing groups GO:0051536 iron-sulfur cluster binding GO:0004532 exoribonuclease activity GO:0016776 phosphotransferase activity, phosphate group as acceptor GO:0015075 ion transmembrane transporter activity GO:0015077 monovalent inorganic cation transmembrane transporter activity GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor GO:0032559 adenyl ribonucleotide binding GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000975 regulatory region DNA binding GO:0032555 purine ribonucleotide binding GO:0015175 neutral amino acid transmembrane transporter activity GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0015079 potassium ion transmembrane transporter activity GO:0015171 amino acid transmembrane transporter activity GO:0032553 ribonucleotide binding GO:0008022 protein C-terminus binding GO:0005342 organic acid transmembrane transporter activity GO:0033613 activating transcription factor binding GO:0008028 monocarboxylic acid transmembrane transporter activity GO:0008146 sulfotransferase activity GO:0008144 drug binding GO:0031490 chromatin DNA binding GO:0042054 histone methyltransferase activity GO:1901681 sulfur compound binding GO:0043565 sequence-specific DNA binding GO:0043566 structure-specific DNA binding GO:1901682 sulfur compound transmembrane transporter activity GO:0000287 magnesium ion binding GO:0005509 calcium ion binding GO:0016410 N-acyltransferase activity GO:0005504 fatty acid binding GO:0005506 iron ion binding GO:0005507 copper ion binding GO:0015926 glucosidase activity GO:0008324 cation transmembrane transporter activity GO:0008289 lipid binding GO:0051015 actin filament binding GO:0001653 peptide receptor activity GO:0048037 cofactor binding GO:0035091 phosphatidylinositol binding GO:0033293 monocarboxylic acid binding GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GO:0016854 racemase and epimerase activity GO:0016853 isomerase activity GO:0047485 protein N-terminus binding GO:0016859 cis-trans isomerase activity GO:0004197 cysteine-type endopeptidase activity GO:0043492 ATPase activity, coupled to movement of substances GO:0017046 peptide hormone binding GO:0017124 SH3 domain binding GO:0017048 Rho GTPase binding GO:0004672 protein kinase activity GO:0001883 purine nucleoside binding GO:0070491 repressing transcription factor binding GO:0015215 nucleotide transmembrane transporter activity GO:0003735 structural constituent of ribosome GO:0015267 channel activity GO:0003730 mRNA 3'-UTR binding GO:0001882 nucleoside binding GO:0019210 kinase inhibitor activity GO:0019213 deacetylase activity GO:0003924 GTPase activity GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GO:0072341 modified amino acid binding GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors GO:0008514 organic anion transmembrane transporter activity GO:0032451 demethylase activity GO:0022857 transmembrane transporter activity GO:0070011 peptidase activity, acting on L-amino acid peptides GO:0004497 monooxygenase activity GO:0015645 fatty acid ligase activity GO:0005261 cation channel activity GO:0005262 calcium channel activity GO:0031267 small GTPase binding GO:0031593 polyubiquitin binding GO:0016597 amino acid binding GO:0004364 glutathione transferase activity GO:0005543 phospholipid binding GO:0004402 histone acetyltransferase activity GO:0005546 phosphatidylinositol-4,5-bisphosphate binding GO:0016740 transferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0005319 lipid transporter activity GO:0004222 metalloendopeptidase activity GO:0051119 sugar transmembrane transporter activity GO:0051117 ATPase binding GO:0016209 antioxidant activity GO:0004386 helicase activity GO:0008173 RNA methyltransferase activity GO:0008170 N-methyltransferase activity GO:0008171 O-methyltransferase activity GO:0008175 tRNA methyltransferase activity GO:0019829 cation-transporting ATPase activity GO:0004702 receptor signaling protein serine/threonine kinase activity GO:0016298 lipase activity GO:0018024 histone-lysine N-methyltransferase activity GO:0001012 RNA polymerase II regulatory region DNA binding GO:0001159 core promoter proximal region DNA binding GO:0001158 enhancer sequence-specific DNA binding GO:0051020 GTPase binding GO:0008083 growth factor activity GO:0046914 transition metal ion binding GO:0046915 transition metal ion transmembrane transporter activity GO:0020037 heme binding GO:0030145 manganese ion binding GO:0017016 Ras GTPase binding GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0008227 G-protein coupled amine receptor activity GO:0001085 RNA polymerase II transcription factor binding GO:0022890 inorganic cation transmembrane transporter activity GO:0022892 substrate-specific transporter activity GO:0050897 cobalt ion binding GO:0019001 guanyl nucleotide binding GO:0019003 GDP binding GO:0046983 protein dimerization activity GO:0046982 protein heterodimerization activity GO:0003743 translation initiation factor activity GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters GO:0016791 phosphatase activity GO:0016790 thiolester hydrolase activity GO:0048306 calcium-dependent protein binding GO:0004521 endoribonuclease activity GO:0019955 cytokine binding GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds GO:0016798 hydrolase activity, acting on glycosyl bonds GO:0019899 enzyme binding GO:0004857 enzyme inhibitor activity GO:0016491 oxidoreductase activity GO:0001948 glycoprotein binding GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0008194 UDP-glycosyltransferase activity GO:0004527 exonuclease activity GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0004520 endodeoxyribonuclease activity GO:0008422 beta-glucosidase activity GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen GO:0032561 guanyl ribonucleotide binding GO:0046943 carboxylic acid transmembrane transporter activity GO:0016667 oxidoreductase activity, acting on a sulfur group of donors GO:0032403 protein complex binding GO:0016877 ligase activity, forming carbon-sulfur bonds GO:0002020 protease binding GO:0033218 amide binding GO:0044822 poly(A) RNA binding GO:0008135 translation factor activity, nucleic acid binding GO:0051427 hormone receptor binding GO:0015144 carbohydrate transmembrane transporter activity GO:0031625 ubiquitin protein ligase binding GO:0016407 acetyltransferase activity GO:0005516 calmodulin binding GO:0005515 protein binding GO:0005100 Rho GTPase activator activity GO:0005102 receptor binding GO:0005518 collagen binding GO:0016409 palmitoyltransferase activity GO:0004177 aminopeptidase activity GO:0004175 endopeptidase activity GO:0003676 nucleic acid binding GO:0030246 carbohydrate binding GO:0008047 enzyme activator activity GO:0016846 carbon-sulfur lyase activity GO:0016840 carbon-nitrogen lyase activity GO:0004180 carboxypeptidase activity GO:0016849 phosphorus-oxygen lyase activity GO:0005215 transporter activity GO:0004674 protein serine/threonine kinase activity GO:0042162 telomeric DNA binding GO:0016247 channel regulator activity GO:0008134 transcription factor binding GO:0061135 endopeptidase regulator activity GO:0061134 peptidase regulator activity GO:0005216 ion channel activity GO:0042626 ATPase activity, coupled to transmembrane movement of substances GO:0017137 Rab GTPase binding GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors GO:0001047 core promoter binding GO:0001046 core promoter sequence-specific DNA binding GO:0043621 protein self-association GO:0003700 sequence-specific DNA binding transcription factor activity GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity GO:0030414 peptidase inhibitor activity GO:0005267 potassium channel activity GO:0060089 molecular transducer activity GO:1901363 heterocyclic compound binding GO:0015085 calcium ion transmembrane transporter activity GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor GO:0060589 nucleoside-triphosphatase regulator activity GO:0008509 anion transmembrane transporter activity GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0042562 hormone binding GO:0046873 metal ion transmembrane transporter activity GO:0046872 metal ion binding GO:0005099 Ras GTPase activator activity GO:0005096 GTPase activator activity GO:0019901 protein kinase binding GO:0019900 kinase binding GO:0019903 protein phosphatase binding GO:0019902 phosphatase binding GO:0019905 syntaxin binding GO:0019904 protein domain specific binding GO:0045182 translation regulator activity GO:0032549 ribonucleoside binding GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0016757 transferase activity, transferring glycosyl groups GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0016758 transferase activity, transferring hexosyl groups GO:0033558 protein deacetylase activity GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity GO:0001071 nucleic acid binding transcription factor activity GO:0042393 histone binding GO:0016278 lysine N-methyltransferase activity GO:0016279 protein-lysine N-methyltransferase activity GO:0016881 acid-amino acid ligase activity GO:0016887 ATPase activity GO:0003677 DNA binding GO:0003678 DNA helicase activity GO:0008168 methyltransferase activity GO:0042625 ATPase activity, coupled to transmembrane movement of ions GO:0016289 CoA hydrolase activity GO:0042623 ATPase activity, coupled GO:0008017 microtubule binding GO:0000149 SNARE binding GO:0019838 growth factor binding GO:0046527 glucosyltransferase activity GO:0005253 anion channel activity GO:0005254 chloride channel activity GO:0005524 ATP binding GO:0005525 GTP binding GO:0035258 steroid hormone receptor binding GO:0035251 UDP-glucosyltransferase activity GO:0016301 kinase activity GO:0035257 nuclear hormone receptor binding GO:0003824 catalytic activity GO:0004812 aminoacyl-tRNA ligase activity GO:0003823 antigen binding GO:0008094 DNA-dependent ATPase activity GO:0016838 carbon-oxygen lyase activity, acting on phosphates GO:0008092 cytoskeletal protein binding GO:0097159 organic cyclic compound binding GO:0016836 hydro-lyase activity GO:0031406 carboxylic acid binding GO:0016831 carboxy-lyase activity GO:0016832 aldehyde-lyase activity GO:0016833 oxo-acid-lyase activity GO:1901618 organic hydroxy compound transmembrane transporter activity GO:0004601 peroxidase activity GO:0017022 myosin binding GO:0042578 phosphoric ester hydrolase activity GO:0008238 exopeptidase activity GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GO:0060590 ATPase regulator activity GO:0008233 peptidase activity GO:0008234 cysteine-type peptidase activity GO:0008237 metallopeptidase activity GO:0008236 serine-type peptidase activity GO:0043168 anion binding GO:0043169 cation binding GO:0042379 chemokine receptor binding GO:0019783 small conjugating protein-specific protease activity GO:0051087 chaperone binding GO:0015276 ligand-gated ion channel activity GO:0051082 unfolded protein binding GO:0036459 ubiquitinyl hydrolase activity GO:0003755 peptidyl-prolyl cis-trans isomerase activity GO:0003690 double-stranded DNA binding GO:0003697 single-stranded DNA binding GO:0042802 identical protein binding GO:0042803 protein homodimerization activity GO:0015459 potassium channel regulator activity GO:0016779 nucleotidyltransferase activity GO:0004860 protein kinase inhibitor activity GO:0035326 enhancer binding GO:0004866 endopeptidase inhibitor activity GO:0004867 serine-type endopeptidase inhibitor activity GO:0030551 cyclic nucleotide binding GO:0030554 adenyl nucleotide binding GO:0004518 nuclease activity GO:0004519 endonuclease activity GO:0046906 tetrapyrrole binding GO:0032182 small conjugating protein binding GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0022832 voltage-gated channel activity GO:0016651 oxidoreductase activity, acting on NAD(P)H GO:0016835 carbon-oxygen lyase activity GO:0022839 ion gated channel activity GO:0022838 substrate-specific channel activity GO:0002039 p53 binding GO:0005200 structural constituent of cytoskeleton GO:0044389 small conjugating protein ligase binding GO:0016830 carbon-carbon lyase activity GO:0070566 adenylyltransferase activity GO:0010333 terpene synthase activity GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0005310 dicarboxylic acid transmembrane transporter activity GO:0000976 transcription regulatory region sequence-specific DNA binding GO:0090595 EXPLANATION GO:0015179 L-amino acid transmembrane transporter activity GO:0050662 coenzyme binding GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GO:0030234 enzyme regulator activity GO:0090484 drug transporter activity GO:0008080 N-acetyltransferase activity GO:0036094 small molecule binding GO:0016879 ligase activity, forming carbon-nitrogen bonds GO:0050660 flavin adenine dinucleotide binding GO:0016874 ligase activity GO:0016875 ligase activity, forming carbon-oxygen bonds GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GO:0009055 electron carrier activity GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters GO:0019842 vitamin binding GO:0019843 rRNA binding GO:0004888 transmembrane signaling receptor activity GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters GO:0035064 methylated histone residue binding GO:0051287 NAD binding GO:0001076 RNA polymerase II transcription factor binding transcription factor activity GO:0008276 protein methyltransferase activity GO:0008270 zinc ion binding GO:0008374 O-acyltransferase activity GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0008026 ATP-dependent helicase activity GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity GO:0003714 transcription corepressor activity GO:0003713 transcription coactivator activity GO:0003712 transcription cofactor activity GO:0015238 drug transmembrane transporter activity GO:0016248 channel inhibitor activity GO:0030695 GTPase regulator activity GO:0030165 PDZ domain binding GO:0005496 steroid binding GO:0015605 organophosphate ester transmembrane transporter activity GO:0060090 binding, bridging GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GO:0051213 dioxygenase activity GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0009975 cyclase activity GO:0051219 phosphoprotein binding GO:0097367 carbohydrate derivative binding GO:0043130 ubiquitin binding GO:0005126 cytokine receptor binding GO:0005088 Ras guanyl-nucleotide exchange factor activity GO:0005125 cytokine activity GO:0005080 protein kinase C binding GO:0005083 small GTPase regulator activity GO:0005085 guanyl-nucleotide exchange factor activity GO:0032947 protein complex scaffold GO:1901677 phosphate transmembrane transporter activity GO:0004930 G-protein coupled receptor activity GO:0070035 purine NTP-dependent helicase activity GO:1901476 carbohydrate transporter activity GO:0004540 ribonuclease activity GO:0015149 hexose transmembrane transporter activity GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups GO:0019239 deaminase activity GO:0000989 transcription factor binding transcription factor activity GO:0016763 transferase activity, transferring pentosyl groups GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0022803 passive transmembrane transporter activity GO:0016684 oxidoreductase activity, acting on peroxide as acceptor GO:0015145 monosaccharide transmembrane transporter activity GO:0000982 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0019787 small conjugating protein ligase activity GO:0005337 nucleoside transmembrane transporter activity GO:0005230 extracellular ligand-gated ion channel activity GO:0005231 excitatory extracellular ligand-gated ion channel activity GO:0008013 beta-catenin binding GO:0017111 nucleoside-triphosphatase activity GO:1901981 phosphatidylinositol phosphate binding GO:0042277 peptide binding GO:0000030 mannosyltransferase activity GO:0004725 protein tyrosine phosphatase activity GO:0004722 protein serine/threonine phosphatase activity GO:0004721 phosphoprotein phosphatase activity GO:0005539 glycosaminoglycan binding GO:0016462 pyrophosphatase activity GO:0005249 voltage-gated potassium channel activity GO:1901505 carbohydrate derivative transporter activity GO:0005245 voltage-gated calcium channel activity GO:0005244 voltage-gated ion channel activity GO:0015932 nucleobase-containing compound transmembrane transporter activity GO:0035639 purine ribonucleoside triphosphate binding GO:0004112 cyclic-nucleotide phosphodiesterase activity GO:0098531 direct ligand regulated sequence-specific DNA binding transcription factor activity GO:0016878 acid-thiol ligase activity GO:0048029 monosaccharide binding GO:0001664 G-protein coupled receptor binding GO:0043167 ion binding GO:0042887 amide transmembrane transporter activity GO:0016829 lyase activity GO:0072509 divalent inorganic cation transmembrane transporter activity GO:0015295 solute:hydrogen symporter activity GO:0015294 solute:cation symporter activity GO:0015297 antiporter activity GO:0015291 secondary active transmembrane transporter activity GO:0015293 symporter activity GO:0015298 solute:cation antiporter activity GO:0052689 carboxylic ester hydrolase activity GO:0001104 RNA polymerase II transcription cofactor activity GO:0034061 DNA polymerase activity GO:0001102 RNA polymerase II activating transcription factor binding GO:0015197 peptide transporter activity GO:0008200 ion channel inhibitor activity GO:0008201 heparin binding GO:0043178 alcohol binding GO:0043177 organic acid binding GO:0003727 single-stranded RNA binding GO:0003724 RNA helicase activity GO:0003725 double-stranded RNA binding GO:0003723 RNA binding GO:0003682 chromatin binding GO:0003729 mRNA binding GO:0019203 carbohydrate phosphatase activity GO:0019200 carbohydrate kinase activity GO:0038023 signaling receptor activity GO:0019207 kinase regulator activity GO:0019205 nucleobase-containing compound kinase activity GO:0019208 phosphatase regulator activity GO:0019209 kinase activator activity GO:0004872 receptor activity GO:0004871 signal transducer activity GO:0032550 purine ribonucleoside binding GO:0008528 G-protein coupled peptide receptor activity GO:0050661 NADP binding GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription GO:0051540 metal cluster binding GO:0005057 receptor signaling protein activity GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors GO:0005198 structural molecule activity GO:0015101 organic cation transmembrane transporter activity GO:0022843 voltage-gated cation channel activity GO:0015103 inorganic anion transmembrane transporter activity GO:0015108 chloride transmembrane transporter activity GO:0005179 hormone activity GO:0005178 integrin binding GO:0015631 tubulin binding GO:0005272 sodium channel activity GO:0008408 3'-5' exonuclease activity GO:0022891 substrate-specific transmembrane transporter activity GO:0051183 vitamin transporter activity GO:0070851 growth factor receptor binding GO:0008081 phosphoric diester hydrolase activity GO:0019199 transmembrane receptor protein kinase activity GO:0015036 disulfide oxidoreductase activity